Nobel Medicine Prize awarded to three scientists for discovering how cells adapt to low oxygen supply

Nobel Medicine Prize awarded to three scientists for discovering how cells adapt to low oxygen supply




US researchers William Kaelin and Gregg Semenza and Britain’s
Peter Ratcliffe on Monday shared the Nobel Medicine Prize for
discoveries on how cells sense and adapt to oxygen availability,
the Nobel Assembly said.

“They established the basis for our understanding of how oxygen
levels affect cellular metabolism and physiological function,” the
jury said.

Their research has “paved the way for promising new strategies
to fight anemia, cancer and many other diseases.”

BREAKING NEWS:
The 2019
#NobelPrize
in Physiology or Medicine has been awarded jointly
to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L.
Semenza “for their discoveries of how cells sense and adapt to
oxygen availability.” pic.twitter.com/6m2LJclOoL

— The Nobel Prize (@NobelPrize)
October 7, 2019

The jury said the trio had identified molecular machinery that
regulates the activity of genes in response to varying levels of
oxygen, which is central to a large number of diseases.

“Intense ongoing efforts in academic laboratories and
pharmaceutical companies are now focused on developing drugs that
can interfere with different disease states by either activating or
blocking, the oxygen-sensing machinery,” the jury said.

Kaelin works at the Howard Hughes Medical Institute in the US,
while Semenza is director of the Vascular Research Program at the
John Hopkins Institute for Cell Engineering.

Ratcliffe is director of clinical research at the Francis Crick
Institute in London, and director of the Target Discovery Institute
in Oxford.

Cells can sense and adapt to the oxygen levels. image credit: Youtube/Nobel Prize

Cells can sense and adapt to the oxygen levels. image credit:
Youtube/Nobel Prize

The three will share the Nobel prize sum of nine million Swedish
kronor (about $914,000 or 833,000 euros).

They will receive their prize from King Carl XVI Gustaf at a
formal ceremony in Stockholm on December 10, the anniversary of the
1896 death of scientist Alfred Nobel who created the prizes in his
last will and testament.

Last year, the honour went to immunologists James Allison of the
US and Tasuku Honjo of Japan, for figuring out how to release the
immune system’s brakes to allow it to attack cancer cells more
efficiently.

The winners of this year’s Physics Prize will be revealed on
Tuesday, followed by the Chemistry Prize on Wednesday.

The Literature Prize will be announced on Thursday, with two
laureates to be crowned after a sexual harassment scandal forced
the Swedish Academy to postpone the 2018 award, for the first time
in 70 years.

The Peace Prize will follow on Friday, with bookies predicting a
win for Swedish teen climate activist Greta Thunberg on betting
sites such as Ladbrokes.

The Economics Prize will wrap up the Nobel prize season on
Monday, 14 October.






Technology

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